基于残差决策的自动飞行控制系统远程实时故障诊断

针对自动飞行控制系统结构复杂、关联部件众多,发生故障时诊断时间长,从而影响飞机运行效率的问题,提出一种基于飞机通信寻址报告系统(ACARS)的远程实时故障诊断方案。首先,分析自动飞行控制系统的故障特点,设计搭建检测滤波器;然后,利用ACARS数据链实时发送的自动飞行控制系统的关键信息进行相关部件的残差计算,并根据残差决策算法进行故障诊断及定位;最后,针对不同故障部件残差间的差异大、决策门限无法统一的缺点,提出基于二次差值的残差决策改进算法,减缓了检测对象的整体变化趋势,降低了随机噪声和干扰的影响,避免了将瞬态故障诊断为系统故障的情况。实验仿真结果表明,基于二次差值的改进残差决策算法避免了多决策门限的复杂性,在采样时间为0.1 s的情况下,故障检测所需时间大约为2 s,故障检测时间大幅降低,有效故障检测率大于90%。     

基于局部放电法的矿用高压电缆信号去噪算法研究

干扰噪声直接影响局部放电法有效检测矿用高压电缆故障。基于局部放电法，综合采用理论计算、仿真实验、现场试验的方法，对比分析了短时傅里叶变换和傅里叶分析去噪法的原理和优缺点，提出了一种矿用高压电缆的局部放电去噪算法——小波阈值去噪法，同时，选择了合理的阈值函数和去噪流程。基于此，采用白噪声和连续周期信号作为高压电缆的干扰噪声，进行了模拟仿真实验。结果表明，小波阈值去噪法可有效抑制白噪声，其中，Db2小波性能和去噪效果最好；同时，现场试验结果显示，去噪后信噪比得到了显著增加，验证了小波阈值去噪法的合理性和可靠性。     

光伏用电致发光缺陷检测仪空间分辨率的量化评估

针对光伏用电致发光缺陷检测仪空间分辨率目视判定重复性、准确性差,并且难以量化等问题,提出一套基于卷积神经网络模型的空间分辨率量化评估方法。参照相关标准JJF(闽)1088-2018,采取不同的拍摄条件拍摄并切割出空间分辨率线对图像,对图像进行人工分类。设计卷积神经网络结构,采用卷积层、池化层和全连接层结构,并使用已分类完成的空间分辨率线对图像对模型进行训练。最终使用测试集对模型进行评估,结果表明,模型在测试集上的判别正确率达到99.2%。该方法满足使用要求,可取代目视判别,提高了光伏用电致发光缺陷检测仪空间分辨率判定的准确性与重复性,并为其量化提出了新的解决思路。由于太阳电池片用光致发光缺陷检测仪与光伏用电致发光缺陷检测仪的成像方式类似,该方法可兼容太阳电池片光致发光检测仪的性能评估。     

Performance of near-infrared dyes as effective contrast agents for breast cancer detection through simulation of photoacoustic imaging

ABSTRACT

Targeted photoacoustic imaging using exogenous contrast agents can potentially improve early detection of breast cancer, even at significant depths inside the breast. In this study, computer simulations were performed to compare the photoacoustic performance of 11 different near-infrared (NIR) dyes for detecting tumours deep inside the breast tissue. It was observed that the three high performing NIR dyes produced at least two-fold contrast enhancement of a spherical breast tumour embedded at 4?cm depth inside the breast than those of the corresponding endogenous contrast agents. These three selected dyes were employed to visualize small blood vessels deep inside the breast tissue. Although methylene blue provided the best contrast in visualizing tumour blood vessels at depths beyond 3?cm, considering other factors such as availability of suitable targeting agent, indocyanine green at 800?nm may be preferred over all other dyes for deep breast imaging applications.     

Homogeneous and Universal Detection of Various Targets with a Dual-Step Transduced Toehold Switch Sensor

Toehold switch sensors represent a class of new advances that allow specific targets to trigger in situ expression of a protein reporter. Although they offer unique advantages of a label-free nature and high portability, they generally require repeated sequence design, high expenditure, and laborious optimization of toehold switch sequences according to different targets. To simplify the sensing process further and to improve its practicability, we innovatively introduce a dual-step pre-transduction upon traditional toehold switch sensor. Through two successive toehold-mediated strand-displacement reactions that are initiated, respectively, by a linear and an associative trigger, different DNAs, RNAs, or ligands of functional nucleic acids can be generally transduced into the input of one high-performance toehold switch sensor. This advance greatly increases the target range. Furthermore, the whole process is signal-on, homogeneous, and free of any requirements for complicated operations such as probe labeling, separation, and reconstruction of the toehold switch, being promising and practical even in portable or point-of-care assays.     

Organic mesh template-based laminated object manufacturing to fabricate ceramics with regular micron scaled pore structures

A new aqueous slurry-based laminated object manufacturing process for porous ceramics is proposed: firstly, an organic mesh sheet is pre-paved as a pore-forming template before slurry layer scraping; secondly, the 2D pattern is built with laser outline cutting of the dried mesh–ceramic composite layer; finally, the pore structure is formed after degreasing and sintering. Alumina parts with porosities of 51.5 %, round hole diameters of 80 ± 5 μm were fabricated using 70 wt. % solid content slurry and 100 mesh nylon net. Using an organic mesh as the framework and template not only reduces the risk of damage of the green body but also ensures the regularity, uniformity and connectivity of the micron scaled pore network. The layer-by-layer drying method avoids the delamination phenomenon and improves the paving density. The new method can realize the flexible design of the pore structure by using various organic mesh templates.     

一种5 重real-time PCR筛查转基因水稻方法的建立

以转基因水稻中最常用的CaMV35S启动子、NOS终止子、Cry1Ab/Ac基因、HPT基因及SPS水稻内标基因为研究对象，利用5 种不同的荧光信号（FAM、HEX、Taxas Red、Cy5、Cy5.5）进行多重实时聚合酶链式反应（real-time polymerase chain reaction，real-time PCR）检测方法的研究。通过引物组合筛选、反应体系优化、特异性测试、灵敏度测试、适用性测试等一系列实验，建立了5 重real-time PCR方法，灵敏度可达0.032%。此方法具有灵敏度高、结果准确、通量大等优点，可实现水稻中转基因成分的快速、高效检测。     

基于图像轮廓曲线的拐点检测算法

拐点是图像很重要的特征,包含图像的主要结构信息，拐点检测对图像配准、目标识别和三维重建等任务的处理都有着非常重要的作用。从研究轮廓上点的曲率出发，针对传统基于轮廓的拐点检测算法对噪声和局部变化敏感而造成检测结果不稳定的问题，提出一种间接反映轮廓曲率特性的方法，记为APTD(Accumulation of Point to Tangent Distance)。使用高斯函数对轮廓曲线进行平滑处理，轮廓上点的曲率越大则该点附近的点到该点处切线的距离也越大，根据这一思想，将轮廓上点附近支撑域内的点到该点所对应切线相对距离的累加和作为拐点的判别函数，从而实现轮廓拐点的检测。经由数学推导表明所提出的算法具有合理性和可行性，对比实验分析表明该算法精度高、运算量小、定位准确。